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A THEORETICAL SIMULATION OF HEMATOPOIETIC STEM CELLS DURING OXYGEN FLUCTUATIONS: PREDICTION OF BONE MARROW RESPONSES DURING HEMORRHAGIC SHOCK

13 Oct 2004

Abstract excerpt

The bone marrow (BM) responds to various diseases, including infections and hemorrhagic shock, by generating immune and blood cells. These cells are derived from a finite number of lymphohematopoietic stem cells (LHSC) close to the endosteal region of the BM. This study presumes that studies on LHSC involving proteomics, computational biology, and genomics could be aided by mathematical models. A theoretical...

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PMID: 15489633
DOI: 10.1097/01.shk.0000142185.88094.88

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