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Article

Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein.

The Journal of biological chemistry - 31 Dec 2004

Liu Jianguo, Guan Xiuqin, Tamura Tomohiko, Ozato Keiko, Ma Xiaojing

Abstract excerpt

Interferon regulatory factor-1 (IRF-1) and interferon consensus sequence-binding protein (ICSBP or IRF-8) are two members of the IRF family of transcription factors that play critical roles in interferon signaling in a wide range of host responses to infection and malignancy. Interleukin-12 (IL-12) is a key factor in the induction of innate resistance and generation of T helper type 1 cells and cytotoxic T...

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PMID: 15489234
DOI: 10.1074/jbc.M406565200

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