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Article

No APOEepsilon4 effect on coronary heart disease risk in a cohort with low smoking prevalence: the Whitehall II study.

Atherosclerosis - 1 Nov 2004

Talmud Philippa J, Lewis Sarah J, Hawe Emma, Martin Steve, Acharya Jayshree, Marmot Michael G, Humphries Steve E, Brunner Eric J

Abstract excerpt

Carriers of the APOEepsilon4 allele have consistently shown higher, and epsilon2 carriers have lower, plasma cholesterol and coronary heart disease (CHD) risk compared with epsilon3 homozygotes. An epsilon4:smoking interaction was observed in NPHSII, consistent with context dependency of the epsilon4 effect on CHD risk. In this study, APOE genotype was determined in 3787 male British civil servants followed for...

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Source

Identifiers

PMID: 15488872
DOI: 10.1016/j.atherosclerosis.2004.06.008

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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