Article
Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E epsilon2/epsilon3/epsilon4 genotype.
Lancet (London, England) - 1 Feb 2003
Keavney Bernard, Parish Sarah, Palmer Alison, Clark Sarah, Youngman Linda, Danesh John, McKenzie Colin, Delépine Marc, Lathrop Mark, Peto Richard, Collins Rory
Abstract excerpt
Results from two small studies, involving a total of only 174 cases, have suggested that the increased risk of coronary heart disease conferred by cigarette smoking is substantially affected by genotype at the apolipoprotein E (APOE) epsilon2/epsilon3/epsilon4 polymorphism. We have established APOE genotypes in 4484 patients with acute myocardial infarction diagnosed before the age of 55 years for male and 65...
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