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Apolipoprotein E genotype and the cardiovascular disease risk phenotype: impact of sex and adiposity (the FINGEN study).

Atherosclerosis - 1 Apr 2012

Kofler Bettina M, Miles Elizabeth A, Curtis Peter, Armah Christopher K, Tricon Sabine, Grew Jilly, Napper Frances L, Farrell Leslie, Lietz Georg, Packard Christopher J, Caslake Muriel J, Mathers John C, Williams Christine M, Calder Philip C, Minihane Anne Marie

Abstract excerpt

Here the impact of APOE genotype on CHD risk in UK adults is reported, along with an analysis of APOE genotype × BMI/age/sex interactions. APOE genotype had a significant impact on fasting total:LDL-cholesterol (TC:LDL-C) ratio, triglycerides, % HDL3, and the Framingham 10-year CVD risk score (P<0.05), with an overall trend towards lower and higher risk in E2- and E4-carriers, respectively, relative to the...

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Identifiers

PMID: 22365656
DOI: 10.1016/j.atherosclerosis.2012.01.042

Genes

APOE

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