Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutants.

Abstract excerpt

The rates of mutation to the mar (monoclonal antibody-resistant) genotype of individual influenza virus plaque isolates, obtained from a stock generated after two successive cloning steps, have been determined by the fluctuation test. When a random sample of 60 clones was analyzed, 7 contained a proportion of mar mutants significantly higher than the average, and among them, 2 showed a mutation rate two to three...

Topics

• Antibodies, Monoclonal
• Cell Line
• Genotype
• Influenza A virus
• Kinetics
• Mutation
• Phenotype