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Article

A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence.

Journal of virology - 1 Apr 1992

Pritchard A E, Calenoff M A, Simpson S, Jensen K, Lipton H L

Abstract excerpt

Viral chimeras have been constructed through in vitro manipulations of the infectious cDNA clones of two prototypes of Theiler's murine encephalomyelitis virus: (i) the virulent GDVII strain and (ii) the less virulent BeAn and VL strains. Previous studies have suggested that the phenotypic differences in virulence between the BeAn and GDVII strains map to both the 5' noncoding and the coat protein regions of...

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Identifiers

PMID: 1548749
DOI: 10.1128/JVI.66.4.1951-1958.1992
PMCID: PMC288983

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