Article
A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence.
Journal of virology - 1 Apr 1992
Pritchard A E, Calenoff M A, Simpson S, Jensen K, Lipton H L
Abstract excerpt
Viral chimeras have been constructed through in vitro manipulations of the infectious cDNA clones of two prototypes of Theiler's murine encephalomyelitis virus: (i) the virulent GDVII strain and (ii) the less virulent BeAn and VL strains. Previous studies have suggested that the phenotypic differ...
Topics
- Animals
- Base Sequence
- Brain Diseases
- Cell Line
- Chimera
- Enterovirus Infections
- Maus Elberfeld virus
- Mice
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Polymerase Chain Reaction
- Protein Biosynthesis
- RNA, Viral
- Temperature
- Transcription, Genetic
- Virulence