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Article

Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.

The Journal of clinical endocrinology and metabolism - 1 Apr 2007

Florez Jose C, Jablonski Kathleen A, Sun Maria W, Bayley Nick, Kahn Steven E, Shamoon Harry, Hamman Richard F, Knowler William C, Nathan David M, Altshuler David

Abstract excerpt

CONTEXT: The common P12A polymorphism in PPARG (a target for thiazolidinedione medications) has been consistently associated with type 2 diabetes. OBJECTIVE: We examined whether PPARG P12A affects progression from impaired glucose tolerance to diabetes, or responses to preventive interventions (lifestyle, metformin, or troglitazone vs. placebo). PATIENTS: This study included 3548 Diabetes Prevention Program...

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Identifiers

PMID: 17213274
DOI: 10.1210/jc.2006-2275
PMCID: PMC2267936

Genes

PPARG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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