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Article

The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth.

The Journal of biological chemistry - 17 Dec 2004

Sdek Patima, Ying Haoqiang, Zheng Hongwu, Margulis Alexander, Tang Xiaoren, Tian Kui, Xiao Zhi-Xiong Jim

Abstract excerpt

Retinoblastoma (Rb) protein is a paradigm of tumor suppressors. Inactivation of Rb plays a critical role in the development of human malignancies. MDM2, an oncogene frequently found amplified and overexpressed in a variety of human tumors and cancers, directly interacts and inhibits the p53 tumor suppressor protein. In addition, MDM2 has been shown to stimulate E2F transactivation activity and promote S-phase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15485814
DOI: 10.1074/jbc.M406062200

Genes

MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth.PMID 15485814Read ↗

Enhanced Mdm2 activity inhibits pRB function via ubiquitin‐dependent degradationSemantic proximity Read ↗

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The MDM2 C-terminal Region Binds to TAFII250 and Is Required for MDM2 Regulation of the Cyclin A PromoterSemantic proximity Read ↗

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.Semantic proximity Read ↗

Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.Semantic proximity Read ↗

Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.Semantic proximity Read ↗

The growth arrest function of the human oncoprotein mouse double minute-2 is disabled by downstream mutation in cancer cells.Semantic proximity Read ↗

Mdm2 promotes genetic instability and transformation independent of p53.Semantic proximity Read ↗

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The contribution of the RING finger domain of MDM2 to cell cycle progression.Semantic proximity Read ↗

MDM2 Is a Negative Regulator of p21 , Independent of p53Semantic proximity Read ↗

Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor.Semantic proximity Read ↗

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