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Article

The growth arrest function of the human oncoprotein mouse double minute-2 is disabled by downstream mutation in cancer cells.

Cancer research - 1 Mar 2005

Zhou Ruizhe, Frum Rebecca, Deb Sumitra, Deb Swati P

Abstract excerpt

We have reported earlier that ectopic expression of mouse double minute-2 (MDM2) induces G1 arrest in normal cells. To explain occasional overexpression of MDM2 in cancer cells, we searched for deletion or substitution mutation in the growth suppressor domains of MDM2 in several breast cancer cell lines that overexpress the oncoprotein. Our results suggest the absence of alteration (deletion or substitution) in...

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Source

Identifiers

PMID: 15753382
DOI: 10.1158/0008-5472.CAN-03-3755

Genes

MDM2
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The growth arrest function of the human oncoprotein mouse double minute-2 is disabled by downstream mutation in cancer cells.PMID 15753382Read ↗

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