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Article

Three-dimensional Structure of P-glycoprotein

15 Oct 2004

Abstract excerpt

Multidrug resistance of cancer cells and pathogens is a serious clinical problem. A major factor contributing to drug resistance in cancer is the over-expression of P-glycoprotein, a plasma membrane ATP-binding cassette (ABC) drug efflux pump. Three-dimensional structural data with a resolution limit of approximately 8 A have been obtained from two-dimensional crystals of P-glycoprotein trapped in the...

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PMID: 15485807
DOI: 10.1074/jbc.m410296200

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