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Article

Nucleotide-induced Structural Changes in P-glycoprotein Observed by Electron Microscopy

20 Dec 2007

Abstract excerpt

P-glycoprotein (Pgp) is an ATP hydrolysis driven multidrug efflux pump, which, when overexpressed in the plasma membrane of certain cancers, can lead to the failure of chemotherapy. Previously, we have presented a projection structure of nucleotide-free mouse Pgp from electron microscopic images of lipid monolayer-generated two-dimensional crystals ( Lee, J. Y., Urbatsch, I. L., Senior, A. E., and Wilkens, S....

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PMID: 18093977
DOI: 10.1074/jbc.m707028200

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