Article
Genetic variants associated with predisposition to prostate cancer and potential clinical implications.
Journal of internal medicine - 1 Apr 2012
Goh C L, Schumacher F R, Easton D, Muir K, Henderson B, Kote-Jarai Z, Eeles R A
Abstract excerpt
Prostate cancer is the commonest cancer in the developed world. There is an inherited component to this disease as shown in familial and twin studies. However, the discovery of these variants has been difficult. The emergence of genome-wide association studies has led to the identification of over 46 susceptibility loci. Their clinical utility to predict risk, response to treatment, or treatment toxicity, remains...
Topics
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- International Cooperation
- Male
- Polymorphism, Single Nucleotide
- Prostatectomy
- Prostatic Neoplasms