Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein kinases in chondrocyte signaling and osteoarthritis.

Clinical orthopaedics and related research - 1 Oct 2004

Malemud Charles J

Abstract excerpt

Protein kinases, particularly mitogen-activated protein kinases and receptor-tyrosine kinases play crucial roles in mammalian cellular metabolism by regulating intracellular signaling pathways that control proliferation, differentiation, cytokine gene induction and cytokine responsiveness, matrix metalloproteinase gene expression, mechanical transduction, as well as programmed cell death (apoptosis). Many of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chondrocytes
Share to Chondrogenesis
Share to Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Mitogen-Activated Protein Kinases

Share to Osteoarthritis

Share to Protein Kinases

Share to Receptor Protein-Tyrosine Kinases

Source

Identifiers

PMID: 15480058
DOI: 10.1097/01.blo.0000143802.41885.50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein kinases in chondrocyte signaling and osteoarthritis.PMID 15480058Read ↗

Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint DiseasesSemantic proximity Read ↗

p38 MAPK Signaling in Osteoblast DifferentiationSemantic proximity Read ↗

Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint DiseasesSemantic proximity Read ↗

Janus kinases and their role in growth and diseaseSemantic proximity Read ↗

Proteomic analysis of knee cartilage reveals potential signaling pathways in pathological mechanism of Kashin-Beck disease compared with osteoarthritisSemantic proximity Read ↗

Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritisSemantic proximity Read ↗

Molecular regulation of articular chondrocyte function and its significance in osteoarthritis.Semantic proximity Read ↗

SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expressionSemantic proximity Read ↗

Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Semantic proximity Read ↗

P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture.Semantic proximity Read ↗

Circadian rhythm protein Bmal1 modulates cartilage gene expression in temporomandibular joint osteoarthritis via the MAPK/ERK pathwaySemantic proximity Read ↗

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.