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Article

Dynamics of mutation and recombination in a replicating population of complementing, defective viral genomes.

Journal of molecular biology - 14 Jul 2006

García-Arriaza Juan, Ojosnegros Samuel, Dávila Mercedes, Domingo Esteban, Escarmís Cristina

Abstract excerpt

In a previous study, we documented that serial passage of a biological clone of foot-and-mouth disease virus (FMDV) at high multiplicity of infection (moi) in cell culture resulted in viral populations dominated by defective genomes that included internal in-frame deletions, affecting the L and capsid-coding regions, and were infectious by complementation. In the present study, analyses of the defective genomes...

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Identifiers

PMID: 16797586
DOI: 10.1016/j.jmb.2006.05.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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