Article
A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosus.
Rheumatology (Oxford, England) - 1 Jan 2005
Seelen M A, van der Bijl E A, Trouw L A, Zuiverloon T C M, Munoz J R, Fallaux-van den Houten F C, Schlagwein N, Daha M R, Huizinga T W J, Roos A
Abstract excerpt
OBJECTIVE: To investigate the possible association of the mannose binding lectin (MBL) pathway of complement activation with different disease parameters and disease activity in patients with systemic lupus erythematosus (SLE). METHODS: MBL genotype, MBL serum concentration, MBL complex activity and MBL pathway activity were assessed in 53 patients. The activity of the MBL-MASP complex was assessed on the basis...
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