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Article

Butyrate increases the efficiency of translation of γ-globin mRNA

13 Oct 2004

Abstract excerpt

Fetal hemoglobin (Hb F) levels increase in most patients with sickle cell disease following intermittent butyrate therapy. Although the full effects of butyrate on Hb F levels usually require multiple treatment cycles, in some patients a peak level is achieved after a few days of butyrate therapy. Our investigation of the mechanism(s) responsible for this rapid induction of Hb F by butyrate showed that...

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PMID: 15479724
DOI: 10.1182/blood-2004-02-0454

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