Article
Fetal globin gene inducers: novel agents and new potential.
Annals of the New York Academy of Sciences - 1 Aug 2010
Perrine Susan P, Castaneda Serguei A, Chui David H K, Faller Douglas V, Berenson Ronald J, Siritanaratku Noppadol, Fucharoen Suthat
Abstract excerpt
Inducing expression of endogenous fetal globin (gamma-globin) gene expression to 60-70% of alpha globin synthesis produces beta-thalassemia trait globin synthetic ratios and can reduce anemia to a mild level. Several classes of therapeutics have induced gamma-globin expression in beta-thalassemia patients and subsequently raised total hemoglobin levels, demonstrating proof-of-concept of the approach. Butyrate...
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