The relative levels of different types of beta-mRNA and beta-globin in BFU-E derived colonies from patients with beta chain variants; further evidence for somatic mosaicism in the Hb Costa Rica carrier [beta 77(EF1)His-->Arg].

doi:10.3109/03630269609027929

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Article

The relative levels of different types of beta-mRNA and beta-globin in BFU-E derived colonies from patients with beta chain variants; further evidence for somatic mosaicism in the Hb Costa Rica carrier [beta 77(EF1)His-->Arg].

Hemoglobin - 1 Aug 1996

Smetanina N S, Gu L H, Rodriguez Romero W E, Howard E F, Huisman T H

Abstract excerpt

We have identified and quantitated the different types of mRNA in single BFU-E derived colonies from Hb S and Hb Atlanta [beta 75 (E19)Leu-->Pro] heterozygotes and observed that the normal and mutated mRNAs were present in equal quantities. Similar studies for the different protein products gave...

Topics

Erythroid Precursor Cells
Globins
Hemoglobins, Abnormal
Humans
Mutation
RNA, Messenger

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