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Article

A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

14 Jan 1993

Abstract excerpt

BACKGROUND: Fetal-globin (gamma-globin) chains inhibit the polymerization of hemoglobin S (sickle hemoglobin) and can functionally substitute for the beta-globin chains that are defective or absent in patients with the beta-thalassemias. Identifying safe mechanisms to stimulate fetal-hemoglobin production is therefore of great interest. Previous studies have shown that administering butyrate selectively...

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Identifiers

PMID: 7677966
DOI: 10.1056/nejm199301143280202

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Related research

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Research trail→

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A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin DisordersPMID 7677966Read ↗

Fetal globin gene inducers: novel agents and new potential.Semantic proximity Read ↗

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Butyrate increases the efficiency of translation of γ-globin mRNASemantic proximity Read ↗

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Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial.Semantic proximity Read ↗

Induction of fetal hemoglobin through enhanced translation efficiency of γ-globin mRNASemantic proximity Read ↗

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Oral isobutyramide reduces transfusion requirements in some patients with homozygous beta-thalassemia.Semantic proximity Read ↗

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