Article
Pharmacological chaperone action on G-protein-coupled receptors.
Current opinion in pharmacology - 1 Oct 2004
Bernier Virginie, Bichet Daniel G, Bouvier Michel
Abstract excerpt
An increasing number of genetic diseases are found to result from mutations that lead to retention of the affected proteins in the endoplasmic reticulum, where they are recognized as misfolded by the quality control system. Several of these conformational diseases involve mutations in G-protein-coupled receptors. Recent studies demonstrated that pharmacologically selective compounds, termed pharmacological...
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