Article
T393C polymorphism of GNAS1 associated with the autonomic nervous system in young, healthy Japanese subjects.
Clinical and experimental pharmacology & physiology - 1 Sept 2004
Yasuda Koichiro, Matsunaga Tetsuro, Moritani Toshio, Nishikino Mariko, Gu Ning, Yoshinaga Mariko, Nagasumi Kae, Yamamura Tsubasa, Aoki Norihiko, Tsuda Kinsuke
Abstract excerpt
1. T393C polymorphism of the gene encoding the Gs-protein alpha-subunit (GNAS1) has been reported recently to be associated with hypertension in which dysfunctions of the autonomic nervous system (ANS) are closely involved. In the present study, the association of this polymorphism with ANS activity was investigated in young, healthy Japanese males. 2. Four hundred and one subjects were genotyped for the T393C...
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