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Article

A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines.

1 Jan 2004

Abstract excerpt

BACKGROUND: Tumor cell lines are commonly used as experimental tools in cancer research, but their relevance for the in vivo situation is debated. In a series of 11 microsatellite stable (MSS) and 9 microsatellite unstable (MSI) colon cancer cell lines and primary colon carcinomas (25 MSS and 28 MSI) with known ploidy stem line and APC, KRAS, and TP53 mutation status, we analyzed the promoter methylation of the...

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PMID: 15476557
DOI: 10.1186/1476-4598-3-28

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