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Article

Functional Characterization and Drug Response of Freshly Established Patient-Derived Tumor Models with CpG Island Methylator Phenotype.

PloS one - 1 Jan 2015

Maletzki Claudia, Huehns Maja, Knapp Patrick, Waukosin Nancy, Klar Ernst, Prall Friedrich, Linnebacher Michael

Abstract excerpt

Patient-individual tumor models constitute a powerful platform for basic and translational analyses both in vitro and in vivo. However, due to the labor-intensive and highly time-consuming process, only few well-characterized patient-derived cell lines and/or corresponding xenografts exist. In this study, we describe successful generation and functional analysis of novel tumor models from patients with sporadic...

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Identifiers

PMID: 26618628
DOI: 10.1371/journal.pone.0143194
PMCID: PMC4664421

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Source receipt: pubmed, retrieved 7 Sept 2026.

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