Article
A promoter polymorphism in the central MHC gene, IKBL, influences the binding of transcription factors USF1 and E47 on disease-associated haplotypes.
Gene expression - 1 Jan 2004
Boodhoo Alvin, Wong Agnes M L, Williamson David, Voon Dominic, Lee Silvia, Allcock Richard J N, Price Patricia
Abstract excerpt
The human major histocompatibility complex (MHC) contains genes that affect susceptibility to numerous immunopathological diseases. We propose that genes in the central MHC between TNFA and HLA-B explain associations between the 8.1 haplotype (HLA-A1, B8, DR3) and disease. IKBL encodes a protein resembling members of the IkappaB protein family that regulate bioavailability of NFkappaB. We have identified two...
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