Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.

Abstract excerpt

Endocytosis modulates the Notch signaling pathway in both the signaling and receiving cells. One recent hypothesis is that endocytosis of the ligand Delta by the signaling cells is essential for Notch activation in the receiving cells. Here, we present evidence in strong support of this model. We show that in the developing Drosophila eye Fat facets (Faf), a deubiquitinating enzyme, and its substrate Liquid...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endocytosis
• Share to Endopeptidases
• Share to Eye