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Article

Drosophila Ndfip is a novel regulator of Notch signaling.

Cell death and differentiation - 1 Jul 2011

Dalton H E, Denton D, Foot N J, Ho K, Mills K, Brou C, Kumar S

Abstract excerpt

In the Drosophila wing, the Nedd4 ubiquitin ligases (E3s), dNedd4 and Su(dx), are important negative regulators of Notch signaling; they ubiquitinate Notch, promoting its endocytosis and turnover. Here, we show that Drosophila Nedd4 family interacting protein (dNdfip) interacts with the Drosophila Nedd4-like E3s. dNdfip expression dramatically enhances dNedd4 and Su(dx)-mediated wing phenotypes and further...

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Source

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Identifiers

PMID: 20966964
DOI: 10.1038/cdd.2010.130
PMCID: PMC3131964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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