Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of a polyclonal antiserum for the detection of the isoforms of the receptors for human growth hormone-releasing hormone on tumors.

Proceedings of the National Academy of Sciences of the United States of America - 19 Oct 2004

Toller Gabor L, Horvath Judit E, Schally Andrew V, Halmos Gabor, Varga Jozsef L, Groot Kate, Chism David, Zarandi Marta

Abstract excerpt

Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of various human cancers by multiple mechanisms, which include direct effects on tumor cells through the splice variants (SV) of the GHRH receptor. Our findings suggest that the tumoral protein encoded by SV 1 (SV1) is a likely functional receptor. The aim of this study was to develop a polyclonal antiserum against a polypeptide analog of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Lymphoma, Non-Hodgkin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Nude

Share to Protein Isoforms

Share to Rabbits

Share to Receptors, Neuropeptide

Share to Receptors, Pituitary Hormone-Regulating Hormone

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 15469915
DOI: 10.1073/pnas.0406348101
PMCID: PMC524040

Genes

GHRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of a polyclonal antiserum for the detection of the isoforms of the receptors for human growth hormone-releasing hormone on tumors.PMID 15469915Read ↗

The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissuesSemantic proximity Read ↗

Knocking down gene expression for growth hormone-releasing hormone inhibits proliferation of human cancer cell linesSemantic proximity Read ↗

Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancersSemantic proximity Read ↗

Expression of mRNA for growth hormone-releasing hormone and splice variants of GHRH receptors in human malignant bone tumors.Semantic proximity Read ↗

Stimulation of proliferation of MCF-7 breast cancer cells by a transfected splice variant of growth hormone-releasing hormone receptorSemantic proximity Read ↗

Human growth hormone-variant demonstrates a receptor binding profile distinct from that of normal pituitary growth hormone.Semantic proximity Read ↗

Using the PET/CT radiotracer [68Ga]Ga-DOTA-mDesmo to target V1b receptors and localize corticotropinoma in Cushing’s diseaseSemantic proximity Read ↗

Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptorSemantic proximity Read ↗

Application of an immune-tolerizing procedure to generate monoclonal antibodies specific to an alternate protein isoform of bovine growth hormone.Semantic proximity Read ↗

Production and characterisation of deletion mutants of ovine growth hormone.Semantic proximity Read ↗

The human placental growth hormone variant is mitogenic for rat lymphoma Nb2 cells.Semantic proximity Read ↗

Identification and pharmacological characterization of native, functional human urotensin‐II receptors in rhabdomyosarcoma cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.