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Using the PET/CT radiotracer [68Ga]Ga-DOTA-mDesmo to target V1b receptors and localize corticotropinoma in Cushing’s disease

22 Aug 2025

Abstract excerpt

Cushing’s disease, the most common cause of Cushing’s syndrome, is driven by pituitary tumors (corticotropinoma) and characterized by the overexpression of CRH R1 and V1b receptors. Accurate detection of these tumors remains challenging. This study aims to develop and evaluate a corticotropinoma specific radiopharmaceutical, [68Ga]Ga-DOTA-mDesmo, that targets the V1b receptor for both anatomical and functional...

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PMID: 40846780
DOI: 10.1038/s43856-025-01033-z

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