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The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues

18 Nov 2005

Abstract excerpt

Various attempts to detect human pituitary growth hormone-releasing hormone receptor (pGHRH-R) in neoplastic extrapituitary tissues have thus far failed. Recently, four splice variants (SVs) of GHRH-R have been described, of which SV1 has the highest structural homology to pGHRH-R and likely plays a role in tumor growth. The aim of this study was to reinvestigate whether human tumors and normal human...

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PMID: 16299104
DOI: 10.1073/pnas.0506844102

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