The human placental growth hormone variant is mitogenic for rat lymphoma Nb2 cells.

doi:10.1210/endo-126-2-971

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Article

The human placental growth hormone variant is mitogenic for rat lymphoma Nb2 cells.

Endocrinology - 1 Feb 1990

Nickel B E, Kardami E, Cattini P A

Abstract excerpt

Although there is evidence that human (h) placental GH variant (hGH-V) possesses a growth-promoting function, lactogenic activity by the hormone has not been demonstrated. Rat anterior pituitary tumor (GC) cells stably transfected with the hGH-V gene (GC [hGH-V] cells) synthesize and secrete hGH-V. This hormone shares considerable structural similarity with pituitary growth hormone (hGH-N) and chorionic...

Topics

Amino Acid Sequence
Animals
Cell Division
Cell Line
Genetic Variation
Growth Hormone
Humans
Immunoblotting
Lymphoma
Molecular Sequence Data
Pituitary Gland, Anterior
Placenta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prolactin

Rats

Recombinant Proteins

Sequence Homology, Nucleic Acid

Transfection

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 2298178
DOI: 10.1210/endo-126-2-971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2298178-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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