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The Folate Receptor α Is Frequently Overexpressed in Osteosarcoma Samples and Plays a Role in the Uptake of the Physiologic Substrate 5-Methyltetrahydrofolate

1 May 2007

Abstract excerpt

PURPOSE: Two major systems exist for folate cell entry: the reduced folate carrier (RFC) and the folate receptor (FR). Although defective RFC-mediated transport was frequently identified as a mechanism of methotrexate (MTX) resistance in osteosarcoma, the status of FR and its role in this disease are unknown. EXPERIMENTAL DESIGN: mRNA for FR alpha was measured in 107 osteosarcoma specimens using quantitative...

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PMID: 17473184
DOI: 10.1158/1078-0432.ccr-06-1343

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