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Article

Genetic and epigenetic alterations of the reduced folate carrier in untreated diffuse large B-cell lymphoma.

European journal of haematology - 1 Jan 2008

Kastrup Ingelise Bjerring, Worm Jesper, Ralfkiaer Elisabeth, Hokland Peter, Guldberg Per, Grønbaek Kirsten

Abstract excerpt

The reduced folate carrier (RFC) is a transmembrane protein that mediates cellular uptake of reduced folates and antifolate drugs, including methotrexate (MTX). Acquired alterations of the RFC gene have been associated with resistance to MTX in cancer cell lines and primary osteosarcomas. Here, we examined RFC for mutations and promoter hypermethylation in (i) the inherently MTX-resistant lymphoma cell line (RL);...

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Identifiers

PMID: 18028428
DOI: 10.1111/j.1600-0609.2007.00980.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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