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Article

Familial insensitivity to pain (HSAN V) and a mutation in the NGFB gene. A neurophysiological and pathological study.

Muscle & nerve - 1 Dec 2004

Minde Jan, Toolanen Göran, Andersson Thomas, Nennesmo Inger, Remahl Ingela Nilsson, Svensson Olle, Solders Göran

Abstract excerpt

We have studied a large Swedish family with a mutation in the nerve growth factor beta (NGFB) gene causing insensitivity to deep pain without anhidrosis (hereditary sensory and autonomic neuropathy, type V; HSAN V). Painfree joint destruction and fractures were common. Peripheral nerve conduction was normal, but temperature thresholds were increased. Sural nerve biopsies showed a moderate loss of A delta fibers...

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Identifiers

PMID: 15468048
DOI: 10.1002/mus.20172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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