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Article

<b><i>PTEN</i></b>Gene Targeting Reveals a Radiation-Induced Size Checkpoint in Human Cancer Cells

1 Oct 2004

Abstract excerpt

Following DNA damage, human cells arrest primarily in the G(1) and G(2) phases of the cell cycle. Here, we show that after irradiation, human cancer cells with targeted deletion of PTEN or naturally occurring PTEN mutations can exert G(1) and G(2) arrests but are unable to arrest in size. Pharmacological inhibition of phosphoinositol-3-kinase or mTOR in PTEN(-/-) cells restored the size arrest, whereas...

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Identifiers

PMID: 15466180
DOI: 10.1158/0008-5472.can-04-1767

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