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Article

PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.

Journal of neuro-oncology - 1 Feb 2005

Nakamura Jean L, Karlsson Amelia, Arvold Nils D, Gottschalk Alexander R, Pieper Russell O, Stokoe David, Haas-Kogan Daphne A

Abstract excerpt

The phosphoinositide 3-kinase (PI3-kinase) signaling pathway is frequently aberrantly activated in glioblastoma multiforme (GM) by mutation or loss of the 3' phospholipid phosphatase PTEN. PTEN abnormalities result in inappropriate signaling to downstream molecules including protein kinase B (PKB/Akt), and mammalian target of rapamycin (mTOR). PI3-kinase activation increases resistance to radiation-induced cell...

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Identifiers

PMID: 15735908
DOI: 10.1007/s11060-004-1718-y

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.PMID 15735908Read ↗

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