Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells

12 Feb 2019

Abstract excerpt

// Audrey Turchick 1 , Yanfeng Liu 2 , Weixi Zhao 2 , Inessa Cohen 2 and Peter M. Glazer 1,2 1 Department of Genetics, Yale University School of Medicine, New Haven, CT, USA 2 Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA Correspondence to: Peter M. Glazer, email: peter.glazer@yale.edu Keywords : DNA repair; PTEN; RAD51; ATR; 3E10 Received: December 17, 2018 Accepted:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30863489
DOI: 10.18632/oncotarget.26654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cellsPMID 30863489Read ↗

[Synthetic lethality as a new concept for the treatment of cancer].Semantic proximity Read ↗

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation.Semantic proximity Read ↗

A cell-penetrating antibody inhibits human RAD51 via direct binding.Semantic proximity Read ↗

PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous RecombinationSemantic proximity Read ↗

Targeting cell cycle regulation via the G2-M checkpoint for synthetic lethality in melanomaSemantic proximity Read ↗

Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy.Semantic proximity Read ↗

RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational StatusSemantic proximity Read ↗

PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity.Semantic proximity Read ↗

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.Semantic proximity Read ↗

Current views on inducing synthetic lethal RNAi responses in the treatment of cancer.Semantic proximity Read ↗

A lethal combination for cancer cells: synthetic lethality screenings for drug discovery.Semantic proximity Read ↗

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN lossSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.