Article
Development of a clinical grade procedure for generation of mRNA transfected dendritic cells from purified frozen CD34(+) blood progenitor cells.
International journal of immunopathology and pharmacology - 1 Jan 2000
Mu L J, Lazarova P, Gaudernack G, Saeboe-Larssen S, Kvalheim G
Abstract excerpt
Enriched CD34(+) peripheral blood progenitor cells (PBPC) are frequently used as stem cell support in cancer patients following high dose therapy. Since precursor dendritic cells (DCs) originate from haematopoietic progenitor cells, purified CD34(+) cells might also serve as starting cells for ex- vivo production of DC. In the present study we developed a clinical grade procedure for ex- vivo production of DC...
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