Article
Exploring dendritic cell based vaccines targeting survivin for the treatment of head and neck cancer patients.
Journal of translational medicine - 20 Jun 2013
Turksma Annelies W, Bontkes Hetty J, Ruizendaal Janneke J, Scholten Kirsten B J, Akershoek Johanneke, Rampersad Shakila, Moesbergen Laura M, Cillessen Saskia A G M, Santegoets Saskia J A M, de Gruijl Tanja D, Leemans C René, Meijer Chris J L M, Hooijberg Erik
Abstract excerpt
BACKGROUND: New treatment modalities are needed for the treatment of cancers of the head and neck region (HNSCC). Survivin is important for the survival and proliferation of tumor cells and may therefore provide a target for immunotherapy. Here we focused on the ex vivo presence and in vitro induction of survivin specific T cells. METHODS: Tetramer staining and ELIspot assays were used to document the presence of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.