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Article

Comparative analysis of Alu insertion sequences in the APP 5' flanking region in humans and other primates.

Journal of molecular evolution - 1 Jun 2004

Clarimón Jordi, Andrés Aida M, Bertranpetit Jaume, Comas David

Abstract excerpt

Overexpression of the amyloid precursor protein gene (APP) may play a role in the neuropathology of Alzheimer's disease. Therefore, elucidating the mechanisms involved in APP gene regulation is of primary importance, and various cis-acting regulatory elements located in 5' distal regions are known to play a main role. Some of them lie within Alu elements, one of which (Alu1) is only found in humans and apes while...

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Identifiers

PMID: 15461429
DOI: 10.1007/s00239-004-2594-y

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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