Article
Alu-derived old world monkeys exonization event and experimental validation of the LEPR gene.
Molecules and cells - 1 Sept 2010
Huh Jae-Won, Kim Young-Hyun, Kim Dae-Soo, Park Sang-Je, Lee Sang-Rae, Kim Sang-Hyun, Kim Ekyune, Kim Sun-Uk, Kim Myeong-Su, Kim Heui-Soo, Chang Kyu-Tae
Abstract excerpt
The leptin receptor (LEPR) is a crucial regulatory protein that interacts with Leptin. In our analysis of LEPR, novel AluJb-derived alternative transcripts were identified in the genome of the rhesus monkey. In order to investigate the occurrence of AluJb-derived alternative transcripts and the mechanism underlying exonization events, we conducted analyses using a number of primate genomic DNAs and adipose RNAs...
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