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Article

The imbalance between Bim and Mcl‐1 expression controls the survival of human myeloma cells

4 Oct 2004

Abstract excerpt

Multiple myeloma is a fatal B cell malignancy characterized by the accumulation of plasma cells within the bone marrow. IL-6 is a major survival factor for myeloma cells. Bcl-2 protein family regulates pathways to apoptosis that are activated upon growth factor deprivation. Pro-apoptotic proteins that have only a single Bcl-2 homology domain, BH3-only, are potent inducers of apoptosis. In myeloma cells, Mcl-1 has...

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PMID: 15459900
DOI: 10.1002/eji.200424981

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