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Article

Multiple myeloma with 1q21 amplification is highly sensitive to MCL-1 targeting

19 Dec 2019

Abstract excerpt

Prosurvival BCL-2 family proteins are potent inhibitors of apoptosis and often overexpressed in lymphoid malignancies. In multiple myeloma (MM), MCL-1 expression contributes to survival of malignant plasma cells, and overexpression correlates with poor prognosis. In this study, we investigated whether sensitivity to the novel MCL-1 inhibitor S63845 could be predicted using cytogenetics, focusing on amplification...

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PMID: 31856269
DOI: 10.1182/bloodadvances.2019000702

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