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Article

Derivation and study of human epithelial cell lines resistant to killing by chromium trioxide.

Journal of toxicology and environmental health. Part A - 9 Jul 2004

Son Kyung-Hwa, Zhang Mingjun, Rucobo Eliana, Nwaigwe Dwight, Montgomery Frederick, Leffert Hyam

Abstract excerpt

CrO3 is cytotoxic for human epithelial 293 kidney cells over a narrow concentration range of approximately 2-8 microM (D50 approximately 3.0 microM); significantly greater toxicity is observed in clonogenic assays (D50 approximately 0.1-1.0 microM). Survival of a small fraction of cells (< or = 0.1%) at CrO3 concentrations between 10(-5) to 10(-3) M, and first-order kinetics of cytotoxicity, rationalized the...

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Identifiers

PMID: 15205032
DOI: 10.1080/15287390490447304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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