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Article

Disruption of Golgi morphology and trafficking in cells expressing mutant prenylated rab acceptor-1.

The Journal of biological chemistry - 27 Sept 2002

Gougeon Pierre-Yves, Prosser Derek C, Da-Silva Lance F, Ngsee Johnny K

Abstract excerpt

Prenylated Rab acceptor (PRA1) is a protein that binds Rab GTPases and the v-SNARE VAMP2. The protein is localized to the Golgi complex and post-Golgi vesicles. To determine its functional role, we generated a number of point mutations and divided them into three classes based on cellular localization. Class A mutants were retained in the endoplasmic reticulum (ER) and exerted an inhibitory effect on transport of...

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Identifiers

PMID: 12107180
DOI: 10.1074/jbc.M205026200
PMCID: PMC2963639

Genes

VAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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