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Article

Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters.

Molecular carcinogenesis - 1 Nov 2004

Gustavson Mark D, Crawford Howard C, Fingleton Barbara, Matrisian Lynn M

Abstract excerpt

The matrix metalloproteinase-7 (MMP-7) gene is a target of beta-catenin transactivation. Expression of the T-cell factor, Lef-1, enhances transcriptional activation of the human MMP-7 promoter by beta-catenin, but represses activation of the mouse MMP-7 promoter, both activities through consensus Tcf binding sites. The mouse promoter has a single Tcf binding element (mTBE) located downstream of the...

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PMID: 15457508
DOI: 10.1002/mc.20049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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