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Article

Overexpression of mutated Cu,Zn-SOD in neuroblastoma cells results in cytoskeletal change.

American journal of physiology. Cell physiology - 1 Feb 2005

Takamiya Rina, Takahashi Motoko, Park Yong Seek, Tawara Yoshie, Fujiwara Noriko, Miyamoto Yasuhide, Gu Jianguo, Suzuki Keiichiro, Taniguchi Naoyuki

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) involves the progressive degeneration of motor neurons in the spinal cord and the motor cortex. It has been shown that 15-20% of patients with familial ALS (FALS) have defects in the Sod1 gene, which encodes Cu,Zn-superoxide dismutase (SOD). To elucidate the pathological role of mutated Cu,Zn-SOD, we examined the issue of whether mutated Cu,Zn-SOD affects the cell cycle. Mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15456693
DOI: 10.1152/ajpcell.00014.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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