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Article

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS.

Journal of neuropathology and experimental neurology - 1 May 1997

Durham H D, Roy J, Dong L, Figlewicz D A

Abstract excerpt

Mutations in the Cu/Zn-superoxide dismutase (SOD-1) gene underlie some familial cases of amyotrophic lateral sclerosis (FALS), a neurodegenerative disorder characterized by loss of cortical, brainstem, and spinal motor neurons. To investigate the mechanisms responsible for the toxicity of mutant enzyme, SOD-1 cDNAs bearing mutations found in FALS patients (mSOD) were expressed in cultured spinal motor neurons,...

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Identifiers

PMID: 9143265
DOI: 10.1097/00005072-199705000-00008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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