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Article

Differential gene expression in a cell culture model of SOD1-related familial motor neurone disease.

Human molecular genetics - 15 Aug 2002

Kirby Janine, Menzies Fiona M, Cookson Mark R, Bushby Katherine, Shaw Pamela J

Abstract excerpt

Motor neurone disease is caused by mutations in Cu/Zn superoxide dismutase (SOD1) in 15-20% of familial cases, due to a toxic gain of function by the mutant enzyme. However, the underlying mechanism of SOD1-mediated neurodegeneration remains uncertain. By investigating alterations in gene expression in the presence of mutant Cu/Zn SOD, we aimed to identify pathways that contribute to motor neurone injury and cell...

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Share to Cell Survival
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Neuron Disease

Share to Motor Neurons

Share to Oligonucleotide Array Sequence Analysis

Share to Oxidative Stress

Share to Superoxide Dismutase

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Source

Identifiers

PMID: 12165567
DOI: 10.1093/hmg/11.17.2061

Genes

SOD1
ICAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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