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Article

Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons.

Experimental & molecular medicine - 31 Oct 2007

Kim Hyun Jung, Im Wooseok, Kim Seungchan, Kim Sung Hun, Sung Jung Jun, Kim Manho, Lee Kwang Woo

Abstract excerpt

Familial amyotrophic lateral sclerosis (fALS) is caused by mutations in Cu/Zn-superoxide dismutase (SOD1), and SOD1 aggregation and calcium toxicity are involved in neuronal death. However, the effect of altered calcium homeostasis on the SOD1 aggregation is unknown. To investigate whether calcium triggers mutant SOD1 aggregation in vitro, human mutant SOD1 (G93A) was transfected into motor neuronal cell line...

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Identifiers

PMID: 18059133
DOI: 10.1038/emm.2007.63

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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